Record Information
Version3.6
Creation Date2005-11-16 15:48:42 UTC
Update Date2013-05-29 19:29:45 UTC
HMDB IDHMDB00939
Secondary Accession NumbersNone
Metabolite Identification
Common NameS-Adenosylhomocysteine
DescriptionS-Adenosylhomocysteine (AdoHcy) is the immediate precursor of all of the homocysteine produced in the body. The reaction is catalyzed by S-adenosylhomocysteine hydrolase and is reversible with the equilibrium favoring formation of AdoHcy. In vivo, the reaction is driven in the direction of homocysteine formation by the action of the enzyme adenosine deaminase, which converts the second product of the S-adenosylhomocysteine hydrolase reaction, adenosine, to inosine. Except for methyl transfer from betaine and from methylcobalamin in the methionine synthase reaction, AdoHcy is the product of all methylation reactions that involve S-adenosylmethionine (AdoMet) as the methyl donor. Methylation is significant in epigenetic regulation of protein expression via DNA and histone methylation. The inhibition of these AdoMet-mediated processes by AdoHcy is a proven mechanism for metabolic alteration. Because the conversion of AdoHcy to homocysteine is reversible, with the equilibrium favoring the formation of AdoHcy, increases in plasma homocysteine are accompanied by an elevation of AdoHcy in most cases. Disturbances in the transmethylation pathway indicated by abnormal S-adenosylmethionine, S-adenosylhomocysteine or their ratio have been reported in many neurodegenerative diseases, such as dementia, depression or Parkinson's disease. (PMID: 18065573 , 17892439 ).
Structure
Thumb
Synonyms
  1. (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
  2. 2-S-Adenosyl-L-homocysteine
  3. 5'-Deoxy-S-adenosyl-L-homocysteine
  4. 5'-S-(3-Amino-3-carboxypropyl)-5'-thio-L-Adenosine
  5. Adenosyl-homo-CYS
  6. Adenosyl-L-homocysteine
  7. Adenosylhomo-CYS
  8. Adenosylhomocysteine
  9. Adohcy
  10. Formycinylhomocysteine
  11. L-5'-S-(3-Amino-3-carboxypropyl)-5'-thior-Adenosine
  12. L-S-Adenosyl-Homocysteine
  13. L-S-Adenosylhomocysteine
  14. S-(5'-Adenosyl)-L-homocysteine
  15. S-(5'-Deoxyadenosin-5'-yl)-L-homocysteine
  16. S-(5'-Deoxyadenosine-5')-L-homocysteine
  17. S-Adenosyl-homocysteine
  18. S-Adenosyl-L-homocysteine
  19. SAH
Chemical FormulaC14H20N6O5S
Average Molecular Weight384.411
Monoisotopic Molecular Weight384.12158847
IUPAC Name(2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}sulfanyl)butanoic acid
Traditional IUPAC NameS-adenosyl-L-homocysteine
CAS Registry Number979-92-0
SMILES
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O
InChI Identifier
InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChI KeyZJUKTBDSGOFHSH-WFMPWKQPSA-N
Chemical Taxonomy
KingdomOrganic Compounds
Super ClassAmino Acids, Peptides, and Analogues
ClassAmino Acids and Derivatives
Sub ClassGlycoamino Acids and Derivatives
Other Descriptors
  • Aromatic Heteropolycyclic Compounds
  • Purine Nucleosides and Analogues
  • amino acid zwitterion(ChEBI)
Substituents
  • 1,2 Diol
  • Alpha Amino Acid Or Derivative
  • Aminopyrimidine
  • Carboxylic Acid
  • Glycosyl Compound
  • Imidazole
  • Imidazopyrimidine
  • N Glycosyl Compound
  • Oxolane
  • Pentose Monosaccharide
  • Polyamine
  • Primary Aliphatic Amine (Alkylamine)
  • Purine
  • Pyrimidine
  • Saccharide
  • Secondary Alcohol
  • Thioether
Direct ParentGlycoamino Acids and Derivatives
Ontology
StatusDetected and Quantified
Origin
  • Drug metabolite
  • Endogenous
Biofunction
  • Component of Arginine and proline metabolism
  • Component of Glycerophospholipid metabolism
  • Component of Glycine, serine and threonine metabolism
  • Component of Histidine metabolism
  • Component of Methionine metabolism
  • Component of Nicotinate and nicotinamide metabolism
  • Component of Selenoamino acid metabolism
  • Component of Tryptophan metabolism
  • Component of Tyrosine metabolism
  • Component of Ubiquinone biosynthesis
  • Waste products
ApplicationNot Available
Cellular locations
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point209 - 211 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
water solubility4.08 g/LALOGPS
logP-2.4ALOGPS
logP-4ChemAxon
logS-2ALOGPS
pKa (strongest acidic)1.81ChemAxon
pKa (strongest basic)9.5ChemAxon
physiological charge0ChemAxon
hydrogen acceptor count10ChemAxon
hydrogen donor count5ChemAxon
polar surface area182.63ChemAxon
rotatable bond count7ChemAxon
refractivity92.72ChemAxon
polarizability38.41ChemAxon
Spectra
Spectra
Biological Properties
Cellular Locations
  • Mitochondria
  • Nucleus
  • Endoplasmic reticulum
Biofluid Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Urine
Tissue Location
  • Kidney
  • Liver
  • Lymphoblast
  • Myelin
  • Neuron
  • Placenta
  • Prostate
Pathways
NameSMPDB LinkKEGG Link
Betaine MetabolismSMP00123map00260
Carnitine SynthesisSMP00465Not Available
Glycine and Serine MetabolismSMP00004map00260
Methionine MetabolismSMP00033map00270
Normal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified0.46 +/- 0.02 uMElderly (>65 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified0.01 (0.009-0.014) uMAdult (>18 years old)BothNormal
Cerebrospinal Fluid (CSF)Detected and Quantified0.0243 +/- 0.0068 uMNot SpecifiedNot SpecifiedNormal
UrineExpected but not QuantifiedNot ApplicableNot AvailableNot AvailableNormal
  • Not Applicable
Abnormal Concentrations
BiofluidStatusValueAgeSexConditionReference
BloodDetected and Quantified0.016 (0.009-0.025) uMAdult (>18 years old)BothNeurodegenerative diseases
BloodDetected and Quantified0.49 +/- 0.05 uMElderly (>65 years old)BothParkinson's Disease
Cerebrospinal Fluid (CSF)Detected and Quantified0.0269 +/- 0.0062 uMAdult (>18 years old)Not SpecifiedAlzheimer's disease
Associated Disorders and Diseases
Disease References
Neurodegenerative disease
  • Obeid R, Kostopoulos P, Knapp JP, Kasoha M, Becker G, Fassbender K, Herrmann W: Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid. Clin Chem. 2007 Feb;53(2):326-33. Epub 2007 Jan 2. Pubmed: 17200133
Parkinson's disease
  • Cheng H, Gomes-Trolin C, Aquilonius SM, Steinberg A, Lofberg C, Ekblom J, Oreland L: Levels of L-methionine S-adenosyltransferase activity in erythrocytes and concentrations of S-adenosylmethionine and S-adenosylhomocysteine in whole blood of patients with Parkinson's disease. Exp Neurol. 1997 Jun;145(2 Pt 1):580-5. Pubmed: 9217094
Associated OMIM IDs
DrugBank IDNot Available
DrugBank Metabolite IDDBMET00514
Phenol Explorer Compound IDNot Available
Phenol Explorer Metabolite IDNot Available
FoodDB IDFDB022327
KNApSAcK IDNot Available
Chemspider ID388301
KEGG Compound IDC00021
BioCyc IDADENOSYL-HOMO-CYS
BiGG ID33543
Wikipedia LinkSAH
NuGOwiki LinkHMDB00939
Metagene LinkHMDB00939
METLIN ID296
PubChem Compound439155
PDB IDSAH
ChEBI ID16680
References
Synthesis ReferenceHoly, Antonin; Rosenberg, Ivan. Studies on S-adenosyl-L-homocysteine hydrolase. Part XV. An improved synthesis of S-adenosyl-L-homocysteine and related compounds. Collection of Czechoslovak Chemical Communications (1985), 50(7), 1514-18.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Augoustides-Savvopoulou P, Luka Z, Karyda S, Stabler SP, Allen RH, Patsiaoura K, Wagner C, Mudd SH: Glycine N -methyltransferase deficiency: a new patient with a novel mutation. J Inherit Metab Dis. 2003;26(8):745-59. Pubmed: 14739680
  2. Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, Nyati MK, Ahsan A, Kalyana-Sundaram S, Han B, Cao X, Byun J, Omenn GS, Ghosh D, Pennathur S, Alexander DC, Berger A, Shuster JR, Wei JT, Varambally S, Beecher C, Chinnaiyan AM: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 2009 Feb 12;457(7231):910-4. Pubmed: 19212411
  3. Hershfield MS, Kredich NM, Koller CA, Mitchell BS, Kurtzberg J, Kinney TR, Falletta JM: S-adenosylhomocysteine catabolism and basis for acquired resistance during treatment of T-cell acute lymphoblastic leukemia with 2'-deoxycoformycin alone and in combination with 9-beta-D-arabinofuranosyladenine. Cancer Res. 1983 Jul;43(7):3451-8. Pubmed: 6601986
  4. Miller AL: The methionine-homocysteine cycle and its effects on cognitive diseases. Altern Med Rev. 2003 Feb;8(1):7-19. Pubmed: 12611557
  5. Struys EA, Jansen EE, de Meer K, Jakobs C: Determination of S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid by stable-isotope dilution tandem mass spectrometry. Clin Chem. 2000 Oct;46(10):1650-6. Pubmed: 11017945
  6. Wang J, Dudman NP, Wilcken DE: Effects of homocysteine and related compounds on prostacyclin production by cultured human vascular endothelial cells. Thromb Haemost. 1993 Dec 20;70(6):1047-52. Pubmed: 8165599
  7. Palella TD, Schatz RA, Wilens TE, Fox IH: S-Adenosylhomocysteine accumulation and selective cytotoxicity in cultured J Lab Clin Med. 1982 Aug;100(2):269-78. Pubmed: 6980250
  8. van Guldener C, Stehouwer CD: Homocysteine and methionine metabolism in renal failure. Semin Vasc Med. 2005 May;5(2):201-8. Pubmed: 16047272
  9. Muskiet FA: The importance of (early) folate status to primary and secondary coronary artery disease prevention. Reprod Toxicol. 2005 Sep-Oct;20(3):403-10. Pubmed: 15964170
  10. Fowler B: Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. Semin Vasc Med. 2005 May;5(2):77-86. Pubmed: 16047261
  11. Gordon RK, Ginalski K, Rudnicki WR, Rychlewski L, Pankaskie MC, Bujnicki JM, Chiang PK: Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur J Biochem. 2003 Sep;270(17):3507-17. Pubmed: 12919315
  12. Metz J: Cobalamin deficiency and the pathogenesis of nervous system disease. Annu Rev Nutr. 1992;12:59-79. Pubmed: 1354465
  13. Mulder C, Schoonenboom NS, Jansen EE, Verhoeven NM, van Kamp GJ, Jakobs C, Scheltens P: The transmethylation cycle in the brain of Alzheimer patients. Neurosci Lett. 2005 Sep 30;386(2):69-71. Pubmed: 16040194
  14. Delabar U, Kloor D, Luippold G, Muhlbauer B: Simultaneous determination of adenosine, S-adenosylhomocysteine and S-adenosylmethionine in biological samples using solid-phase extraction and high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1999 Mar 19;724(2):231-8. Pubmed: 10219663
  15. Hermes M, von Hippel S, Osswald H, Kloor D: S-adenosylhomocysteine metabolism in different cell lines: effect of hypoxia and cell density. Cell Physiol Biochem. 2005;15(5):233-44. Pubmed: 15956786
  16. Weir DG, Molloy AM, Keating JN, Young PB, Kennedy S, Kennedy DG, Scott JM: Correlation of the ratio of S-adenosyl-L-methionine to S-adenosyl-L-homocysteine in the brain and cerebrospinal fluid of the pig: implications for the determination of this methylation ratio in human brain. Clin Sci (Lond). 1992 Jan;82(1):93-7. Pubmed: 1310924
  17. Wagner C, Koury MJ: S-Adenosylhomocysteine: a better indicator of vascular disease than homocysteine? Am J Clin Nutr. 2007 Dec;86(6):1581-5. Pubmed: 18065573
  18. Herrmann W, Obeid R: Biomarkers of folate and vitamin B(12) status in cerebrospinal fluid. Clin Chem Lab Med. 2007;45(12):1614-20. Pubmed: 17892439

Only showing the first 50 proteins. There are 94 proteins in total.

Enzymes

Gene Name:
PEMT
Uniprot ID:
Q9UBM1
Reactions
S-Adenosylmethionine + phosphatidyl-N-methylethanolamine unknown S-Adenosylhomocysteine + phosphatidyl-N-dimethylethanolaminedetails
S-Adenosylmethionine + phosphatidyl-N-dimethylethanolamine unknown S-Adenosylhomocysteine + phosphatidylcholinedetails
S-Adenosylmethionine + Phosphatidylethanolamine unknown S-Adenosylhomocysteine + phosphatidyl-N-methylethanolaminedetails
S-Adenosylmethionine + Phosphatidyl-N-dimethylethanolamine unknown S-Adenosylhomocysteine + Phosphatidylcholinedetails
S-Adenosylmethionine + Phosphatidylethanolamine unknown S-Adenosylhomocysteine + Phosphatidyl-N-methylethanolaminedetails
Gene Name:
ASMT
Uniprot ID:
P46597
Reactions
S-Adenosylmethionine + N-Acetylserotonin unknown S-Adenosylhomocysteine + Melatonindetails
S-Adenosylmethionine + 5-Hydroxyindoleacetic acid unknown S-Adenosylhomocysteine + 5-Methoxyindoleacetatedetails
Gene Name:
COMT
Uniprot ID:
P21964
Reactions
S-Adenosylmethionine + a catechol unknown S-Adenosylhomocysteine + a guaiacoldetails
S-Adenosylmethionine + Norepinephrine unknown S-Adenosylhomocysteine + Normetanephrinedetails
S-Adenosylmethionine + Epinephrine unknown S-Adenosylhomocysteine + Metanephrinedetails
S-Adenosylmethionine + 3,4-Dihydroxybenzeneacetic acid unknown S-Adenosylhomocysteine + Homovanillic aciddetails
S-Adenosylmethionine + Dopamine unknown S-Adenosylhomocysteine + 3-Methoxytyraminedetails
2-Hydroxyestrone + S-Adenosylmethionine unknown 2-Methoxyestrone + S-Adenosylhomocysteinedetails
2-Hydroxyestradiol + S-Adenosylmethionine unknown 2-Methoxyestradiol + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + 3,4-Dihydroxyphenylglycol unknown S-Adenosylhomocysteine + Vanylglycoldetails
S-Adenosylmethionine + 3,4-Dihydroxymandelic acid unknown S-Adenosylhomocysteine + Vanillylmandelic aciddetails
Gene Name:
DOT1L
Uniprot ID:
Q8TEK3
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
GNMT
Uniprot ID:
Q14749
Reactions
S-Adenosylmethionine + Glycine unknown S-Adenosylhomocysteine + Sarcosinedetails
Gene Name:
SETD7
Uniprot ID:
Q8WTS6
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
PNMT
Uniprot ID:
P11086
Reactions
S-Adenosylmethionine + 2-Hydroxyphenethylamine unknown S-Adenosylhomocysteine + N-Methylphenylethanolaminedetails
S-Adenosylmethionine + Norepinephrine unknown S-Adenosylhomocysteine + Epinephrinedetails
Gene Name:
DPH5
Uniprot ID:
Q9H2P9
Reactions
S-Adenosylmethionine + 2-(3-Carboxy-3-aminopropyl)-L-histidine unknown S-Adenosylhomocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidinedetails
Gene Name:
AS3MT
Uniprot ID:
Q9HBK9
Reactions
S-Adenosylmethionine + Arsenite unknown S-Adenosylhomocysteine + Methylarsonatedetails
S-Adenosylmethionine + Methylarsonite unknown S-Adenosylhomocysteine + Dimethylarsinatedetails
Gene Name:
NSD1
Uniprot ID:
Q96L73
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
SETDB1
Uniprot ID:
Q15047
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
PCMT1
Uniprot ID:
P22061
Reactions
S-Adenosylmethionine + protein L-isoaspartate unknown S-Adenosylhomocysteine + protein L-isoaspartate alpha-methyl esterdetails
Gene Name:
ICMT
Uniprot ID:
O60725
Reactions
S-Adenosylmethionine + protein C-terminal S-farnesyl-L-cysteine unknown S-Adenosylhomocysteine + protein C-terminal S-farnesyl-L-cysteine methyl esterdetails
Gene Name:
INMT
Uniprot ID:
O95050
Reactions
S-Adenosylmethionine + an amine unknown S-Adenosylhomocysteine + a methylated aminedetails
S-Adenosylmethionine + Dimethylsulfide unknown S-Adenosylhomocysteine + Trimethyl sulfoniumdetails
S-Adenosylmethionine + Tryptamine unknown S-Adenosylhomocysteine + N-Methyltryptaminedetails
S-Adenosylmethionine + Serotonin unknown S-Adenosylhomocysteine + N-Methylserotonindetails
S-Adenosylmethionine + Dimethyl selenide unknown S-Adenosylhomocysteine + Trimethylselenoniumdetails
Gene Name:
DNMT3A
Uniprot ID:
Q9Y6K1
Reactions
S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosinedetails
S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosinedetails
Gene Name:
COQ3
Uniprot ID:
Q9NZJ6
Reactions
S-Adenosylmethionine + 3,4-dihydroxy-5-all-trans-polyprenylbenzoate unknown S-Adenosylhomocysteine + 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoatedetails
S-Adenosylmethionine + 3-demethylubiquinone-n unknown S-Adenosylhomocysteine + ubiquinone-ndetails
S-Adenosylmethionine + 3-(all-trans-polyprenyl)benzene-1,2-diol unknown S-Adenosylhomocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenoldetails
2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown Ubiquinone 6 + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + 3-Hexaprenyl-4,5-Dihydroxybenzoic acid unknown S-Adenosylhomocysteine + 3-Hexaprenyl-4-hydroxy-5-methoxybenzoic acid + Hydrogen Iondetails
S-Adenosylmethionine + 3-Demethylubiquinone-9 unknown S-Adenosylhomocysteine + Coenzyme Q9details
3-Polyprenyl-4,5-dihydroxybenzoate + S-Adenosylmethionine unknown 3-Polyprenyl-4-hydroxy-5-methoxybenzoate + S-Adenosylhomocysteinedetails
2-Polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown Ubiquinone-2 + S-Adenosylhomocysteinedetails
Gene Name:
EHMT2
Uniprot ID:
Q96KQ7
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
MTRR
Uniprot ID:
Q9UBK8
Reactions
[methionine synthase]-methylcob(I)alamin + S-Adenosylhomocysteine + NADP unknown [methionine synthase]-cob(II)alamin + NADPH + S-Adenosylmethioninedetails
Gene Name:
SUV39H1
Uniprot ID:
O43463
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
NNMT
Uniprot ID:
P40261
Reactions
S-Adenosylmethionine + Niacinamide unknown S-Adenosylhomocysteine + 1-Methylnicotinamidedetails
S-Adenosylmethionine + Niacinamide + Hydrogen Ion unknown S-Adenosylhomocysteine + 1-Methylnicotinamidedetails
Gene Name:
SUV39H2
Uniprot ID:
Q9H5I1
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
EHMT1
Uniprot ID:
Q9H9B1
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
GAMT
Uniprot ID:
Q14353
Reactions
S-Adenosylmethionine + Guanidoacetic acid unknown S-Adenosylhomocysteine + Creatinedetails
Gene Name:
HNMT
Uniprot ID:
P50135
Reactions
S-Adenosylmethionine + Histamine unknown S-Adenosylhomocysteine + 1-Methylhistaminedetails
Gene Name:
TPMT
Uniprot ID:
P51580
Reactions
S-Adenosylmethionine + a thiopurine unknown S-Adenosylhomocysteine + a thiopurine S-methyletherdetails
Mercaptopurine + S-Adenosylmethionine unknown 6-Methylmercaptopurine + S-Adenosylhomocysteinedetails
6-Thioinosine-5'-monophosphate + S-Adenosylmethionine unknown 6-Methylthiopurine 5'-monophosphate ribonucleotide + S-Adenosylhomocysteinedetails
6-Thioguanosine monophosphate + S-Adenosylmethionine unknown 6-Methylthioguanosine monophosphate + S-Adenosylhomocysteinedetails
Gene Name:
METTL3
Uniprot ID:
Q86U44
Reactions
S-Adenosylmethionine + m(7)G(5')pppAm unknown S-Adenosylhomocysteine + m(7)G(5')pppm(6)Amdetails
Gene Name:
AHCYL2
Uniprot ID:
Q96HN2
Reactions
S-Adenosylhomocysteine + Water unknown Homocysteine + Adenosinedetails
Gene Name:
AHCY
Uniprot ID:
P23526
Reactions
S-Adenosylhomocysteine + Water unknown Homocysteine + Adenosinedetails
Gene Name:
AHCYL1
Uniprot ID:
O43865
Reactions
S-Adenosylhomocysteine + Water unknown Homocysteine + Adenosinedetails
Gene Name:
PRMT5
Uniprot ID:
O14744
Reactions
S-Adenosylmethionine + arginine-[histone] unknown S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone]details
Gene Name:
SETD1A
Uniprot ID:
O15047
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
PRDM2
Uniprot ID:
Q13029
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Gene Name:
MLL
Uniprot ID:
Q03164
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
DNMT3B
Uniprot ID:
Q9UBC3
Reactions
S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosinedetails
S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosinedetails
Gene Name:
TRDMT1
Uniprot ID:
O14717
Reactions
S-Adenosylmethionine + cytosine(38) in tRNA unknown S-Adenosylhomocysteine + 5-methylcytosine(38) in tRNAdetails
Gene Name:
SETD8
Uniprot ID:
Q9NQR1
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
MLL3
Uniprot ID:
Q8NEZ4
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
DNMT1
Uniprot ID:
P26358
Reactions
S-Adenosylmethionine + DNA unknown S-Adenosylhomocysteine + DNA containing 5-methylcytosinedetails
S-Adenosylmethionine + DNA cytosine unknown S-Adenosylhomocysteine + DNA 5-methylcytosinedetails
Gene Name:
SETDB2
Uniprot ID:
Q96T68
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
NSUN2
Uniprot ID:
Q08J23
Reactions
S-Adenosylmethionine + cytosine(34) in tRNA precursor unknown S-Adenosylhomocysteine + 5-methylcytosine(34) in tRNA precursordetails
Gene Name:
COQ5
Uniprot ID:
Q5HYK3
Reactions
S-Adenosylmethionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol unknown S-Adenosylhomocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinoldetails
2-Hexaprenyl-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown 2-Hexaprenyl-3-methyl-6-methoxy-1,4 benzoquinone + S-Adenosylhomocysteinedetails
2-Polyprenyl-6-methoxy-1,4-benzoquinone + S-Adenosylmethionine unknown 2-Polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-Adenosylhomocysteinedetails
Gene Name:
ASH1L
Uniprot ID:
Q9NR48
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
CARM1
Uniprot ID:
Q86X55
Reactions
S-Adenosylmethionine + arginine-[histone] unknown S-Adenosylhomocysteine + N(omega)-methyl-arginine-[histone]details
Gene Name:
EZH2
Uniprot ID:
Q15910
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Gene Name:
RNMT
Uniprot ID:
O43148
Reactions
S-Adenosylmethionine + G(5')pppR-RNA unknown S-Adenosylhomocysteine + m(7)G(5')pppR-RNAdetails
Gene Name:
MLL2
Uniprot ID:
O14686
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
WBP7
Uniprot ID:
Q9UMN6
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
MLL5
Uniprot ID:
Q8IZD2
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails
Gene Name:
WHSC1
Uniprot ID:
O96028
Reactions
S-Adenosylmethionine + L-lysine-[histone] unknown S-Adenosylhomocysteine + N(6)-methyl-L-lysine-[histone]details
Protein lysine + S-Adenosylmethionine unknown Protein N6-methyl-L-lysine + S-Adenosylhomocysteinedetails
S-Adenosylmethionine + Protein N6-methyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6-dimethyl-L-lysinedetails
S-Adenosylmethionine + Protein N6,N6-dimethyl-L-lysine unknown S-Adenosylhomocysteine + Protein N6,N6,N6-trimethyl-L-lysinedetails

Only showing the first 50 proteins. There are 94 proteins in total.